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human tspan12  (Biorbyt)


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    Structured Review

    Biorbyt human tspan12
    Figure 4 | Expression of Norrin signaling components, including Norrin, Frizzled 4, Lrp5 and <t>TSPAN12</t> in endothelial cells in the CRC tumor microenvironment. In column 1, low power (53) micrographs of the tumor microenvironment are depicted. The square demonstrates the region of higher (1003) magnification (columns 2–5). Green fluorescence (column 2) indicates expression of a specific Norrin signaling component (see row designation, below). Red fluorescence (column 3) marks endothelial cells (anti-CD31 positive) of colorectal tumor blood vessels. Blue fluorescence(column 4) depicts DAPI-stained nuclei. Merged images are depicted in column 5. Row (A). Expression of Norrin in colorectal tumor endothelial cells. Row (B). Expression of Frizzled 4 in colorectal tumor endothelial cells. Row (C). Expression of Lrp5 in colorectal tumor endothelial cells. Row (D). Expression of TSPAN12 in colorectal tumor endothelial cells.
    Human Tspan12, supplied by Biorbyt, used in various techniques. Bioz Stars score: 85/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/human tspan12/product/Biorbyt
    Average 85 stars, based on 2 article reviews
    human tspan12 - by Bioz Stars, 2026-03
    85/100 stars

    Images

    1) Product Images from "A novel signaling pathway regulates colon cancer angiogenesis through Norrin."

    Article Title: A novel signaling pathway regulates colon cancer angiogenesis through Norrin.

    Journal: Scientific reports

    doi: 10.1038/srep05630

    Figure 4 | Expression of Norrin signaling components, including Norrin, Frizzled 4, Lrp5 and TSPAN12 in endothelial cells in the CRC tumor microenvironment. In column 1, low power (53) micrographs of the tumor microenvironment are depicted. The square demonstrates the region of higher (1003) magnification (columns 2–5). Green fluorescence (column 2) indicates expression of a specific Norrin signaling component (see row designation, below). Red fluorescence (column 3) marks endothelial cells (anti-CD31 positive) of colorectal tumor blood vessels. Blue fluorescence(column 4) depicts DAPI-stained nuclei. Merged images are depicted in column 5. Row (A). Expression of Norrin in colorectal tumor endothelial cells. Row (B). Expression of Frizzled 4 in colorectal tumor endothelial cells. Row (C). Expression of Lrp5 in colorectal tumor endothelial cells. Row (D). Expression of TSPAN12 in colorectal tumor endothelial cells.
    Figure Legend Snippet: Figure 4 | Expression of Norrin signaling components, including Norrin, Frizzled 4, Lrp5 and TSPAN12 in endothelial cells in the CRC tumor microenvironment. In column 1, low power (53) micrographs of the tumor microenvironment are depicted. The square demonstrates the region of higher (1003) magnification (columns 2–5). Green fluorescence (column 2) indicates expression of a specific Norrin signaling component (see row designation, below). Red fluorescence (column 3) marks endothelial cells (anti-CD31 positive) of colorectal tumor blood vessels. Blue fluorescence(column 4) depicts DAPI-stained nuclei. Merged images are depicted in column 5. Row (A). Expression of Norrin in colorectal tumor endothelial cells. Row (B). Expression of Frizzled 4 in colorectal tumor endothelial cells. Row (C). Expression of Lrp5 in colorectal tumor endothelial cells. Row (D). Expression of TSPAN12 in colorectal tumor endothelial cells.

    Techniques Used: Expressing, Fluorescence, Staining



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    Figure 4 | Expression of Norrin signaling components, including Norrin, Frizzled 4, Lrp5 and <t>TSPAN12</t> in endothelial cells in the CRC tumor microenvironment. In column 1, low power (53) micrographs of the tumor microenvironment are depicted. The square demonstrates the region of higher (1003) magnification (columns 2–5). Green fluorescence (column 2) indicates expression of a specific Norrin signaling component (see row designation, below). Red fluorescence (column 3) marks endothelial cells (anti-CD31 positive) of colorectal tumor blood vessels. Blue fluorescence(column 4) depicts DAPI-stained nuclei. Merged images are depicted in column 5. Row (A). Expression of Norrin in colorectal tumor endothelial cells. Row (B). Expression of Frizzled 4 in colorectal tumor endothelial cells. Row (C). Expression of Lrp5 in colorectal tumor endothelial cells. Row (D). Expression of TSPAN12 in colorectal tumor endothelial cells.
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    Image Search Results


    Figure 4 | Expression of Norrin signaling components, including Norrin, Frizzled 4, Lrp5 and TSPAN12 in endothelial cells in the CRC tumor microenvironment. In column 1, low power (53) micrographs of the tumor microenvironment are depicted. The square demonstrates the region of higher (1003) magnification (columns 2–5). Green fluorescence (column 2) indicates expression of a specific Norrin signaling component (see row designation, below). Red fluorescence (column 3) marks endothelial cells (anti-CD31 positive) of colorectal tumor blood vessels. Blue fluorescence(column 4) depicts DAPI-stained nuclei. Merged images are depicted in column 5. Row (A). Expression of Norrin in colorectal tumor endothelial cells. Row (B). Expression of Frizzled 4 in colorectal tumor endothelial cells. Row (C). Expression of Lrp5 in colorectal tumor endothelial cells. Row (D). Expression of TSPAN12 in colorectal tumor endothelial cells.

    Journal: Scientific reports

    Article Title: A novel signaling pathway regulates colon cancer angiogenesis through Norrin.

    doi: 10.1038/srep05630

    Figure Lengend Snippet: Figure 4 | Expression of Norrin signaling components, including Norrin, Frizzled 4, Lrp5 and TSPAN12 in endothelial cells in the CRC tumor microenvironment. In column 1, low power (53) micrographs of the tumor microenvironment are depicted. The square demonstrates the region of higher (1003) magnification (columns 2–5). Green fluorescence (column 2) indicates expression of a specific Norrin signaling component (see row designation, below). Red fluorescence (column 3) marks endothelial cells (anti-CD31 positive) of colorectal tumor blood vessels. Blue fluorescence(column 4) depicts DAPI-stained nuclei. Merged images are depicted in column 5. Row (A). Expression of Norrin in colorectal tumor endothelial cells. Row (B). Expression of Frizzled 4 in colorectal tumor endothelial cells. Row (C). Expression of Lrp5 in colorectal tumor endothelial cells. Row (D). Expression of TSPAN12 in colorectal tumor endothelial cells.

    Article Snippet: Colorectal tumor slides were triple stained with DAPI (blue) for nuclear DNA, Texas Red (red) for human blood vessel endothelial cells (anti-CD31 mouse monoclonal antibody Abcam (ab 9498) at 1510 dilution, and a secondary antibody conjugate Texas Red-donkey polyclonal against mouse IgG from Abcam (ab 7059) used at 151000 dilution) and FITC (green) for components of Norrin pathway (goat polyclonal directed against human Norrin (R&D, AF 3014), diluted till 1550 from stock 0.2 mg/ml; rabbit polyclonal against human Frizzled 4 (MBL International Corporation, MC-4911), diluted 1540; goat polyclonal against human Lrp 5 (Abcam, ab 36121), diluted 15500; rabbit polyclonal against human TSPAN12 (Biorbyt, orb 39384), diluted at 15100.

    Techniques: Expressing, Fluorescence, Staining